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TAS-115 mesylate (TAS-115 methanesulfonate)
DC12256  (CAS:1688673-09-7)
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Fields of Application :
TAS-115 mesylate is a potent VEGFR and c-Met/HGFR kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.
CAS Number: 1688673-09-7


Molecular Weight: 614.66
Molecular Formula: C28H27FN4O7S2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: TAS115,TAS 115
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
In Vitro TAS-115 powerfully suppresses the VEGF-dependent proliferation of HUVECs (IC50=0.019 M) as a VEGFR-targeted inhibitor and powerfully suppresses the proliferation of MET-amplified cancer cells (GI50=0.032-0.362 M) as a MET-targeted inhibitor. TAS-115 has much less toxicity in various normal cell lines when compared with other VEGFR-targeted kinase inhibitors. Crizotinib and TAS-115 inhibit Met phosphorylation and reverse erlotinib resistance and VEGF production triggered by HGF in PC-9 and HCC827 cells. In Vivo TAS-115 completely suppresses the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of TAS-115. TAS-115 induces marked tumor shrinkage and prolonges survival in MET-amplified human cancerCbearing mice.
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