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TGN-020
DC12042  (CAS:51987-99-6)
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100mg USD 550 in stock
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Fields of Application :
TGN 020 is a thiadiazole derivative studied for its potential antitumor properties
CAS Number: 51987-99-6
Purity:

>98%

Molecular Weight: 206.22
Molecular Formula: C8H6N4OS
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: TGN 020,TGN-020,TGN020,51987-99-6
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Storage: 4 Degree for 1 year, -20 degree for more than 2 years
Note: Products for research use only, not for human use
Description:
TGN 020 is a thiadiazole derivative which has been studied as an antitumoragent. Furthermore, N-(1,3,4-Thiadiazolyl)nicotinamide is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor N-(1,3,4-Thiadiazolyl)nicotinamide significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.
References:
O=C(NC1=NN=CS1)C2=CN=CC=C2
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