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THZ2
DC11282  (CAS:1604810-84-5)
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100mg USD 550 in stock
250mg USD 950 in stock
1g USD 1800 in stock
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Fields of Application :
THZ2 is a potent and selective CDK7 inhibitor with IC50 of 13.9 nM.
CAS Number: 1604810-84-5
Purity:

>98%

Molecular Weight: 566.05
Molecular Formula: C31H28ClN2O2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: THZ-2,THZ2,THZ 2
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
THZ2 selectively targets CDK7 and potently inhibits the growth of triple-negative but not ER/PR+ breast cancer cells. THZ2 at low nanomolar doses also efficiently suppresses the clonogenic growth of TNBC cells with IC50 of appr 10 nM. THZ2 induces apoptotic cell death in triple-negative but not ER/PR+ breast cancer cells or normal human cells.THZ2 (10 mg/Kg) markedly reduces the growth rate of tumors in mice and demonstrates an anti-tumor activity. Compared to vehicle-treated tumors, tumor tissues isolated from mice treated with THZ2 has reduced proliferation and increased apoptosis, as indicated by immunostaining against Ki67 and cleaved Caspase 3 respectively. THZ2 in NOD-SCID mice leads to reduced body weight, suggesting that THZ2 mayt be less well-tolerated in this particular mouse strain.
References:
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN(C)C)=O)=C5
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