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Treprostinil free acid
DC12366  (CAS:81846-19-7)
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Fields of Application :
Treprostinil is a potent DP1 and EP2 agonist with EC50 values of 0.60.1 and 6.21.2 nM, respectively.
CAS Number: 81846-19-7


Molecular Weight: 390.5
Molecular Formula: C23H34O5
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: BW 15AULRX 15RumodolinU-62840Uniprost
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Treprostinil has high affinity for the DP1, EP2 and IP receptors (Ki=4.4, 3.6 and 32 nM, respectively), low affinity for EP1 and EP4 receptors and even lower affinity for EP3, FP and TP receptors. Activation of IP, DP1 and EP2 receptors, as with treprostinil, can all result in vasodilatation of human pulmonary arteries.Inhaled treprostinil sodium, a prostacyclin analog, is the most recent agent to receive FDA approval for the treatment of a fatal orphan disease: pulmonary arterial hypertension (PAH). Treprostinil preserves the sinusoidal endothelial cell lining and reduces platelet deposition early post-transplantation compared to placebo. Hepatic tissue blood flow is significantly compromised in the placebo group, whereas treprostinil maintains blood flow similar to normal levels.
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