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Verdinexor (KPT-335)
DC8429  (CAS:1392136-43-4)
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100mg USD 950 In stock
250mg USD 1700 In stock
1g USD 3300 In stock
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Fields of Application :
Verdinexor (KPT-335) is an orally bioavailable, selective XPO1/CRM1 inhibitor.
CAS Number: 1392136-43-4
Purity:

>98%

Molecular Weight: 442.32
Molecular Formula: C18H12F6N6O
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: KPT-335,KPT 335,KPT335
Chemical Name: (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]- 2-propenoic acid-2-(2-pyridinyl)hydrazide
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
Verdinexor inhibits the viability of Jurkat, OCI-Ly3, OCI-Ly10, and CLBL1 cells with IC50 of 0.3 nM, 2.1 nM, 41.8 nM, and 8.5 nM, respectively. KPT-335 also induces apoptosis in CLBL1 cells and primary canine DLBCL cells that express XPO1 and SINE. Verdinexor potently and selectively inhibits vRNP export and effectively inhibits the replication of various influenza virus A and B strains, including pandemic H1N1 virus, highly pathogenic H5N1 avian influenza virus, and the recently emerged H7N9 strain. Verdinexor (25 mg/kg twice daily, p.o.) reduces proinflammatory cytokine expression in the lung, produces in vivo antiviral activity by reducing lung virus titers, and thus reduces pulmonary disease pathogenesis and death associated with lethal influenza A virus challenge. In autosomal-dominant polycystic kidney disease model, Verdinexor (5 mg/kg, i.p.) attenuates cyst growth via inhibition of XPO1. For the detailed information of Verdinexor (KPT-335), the solubility of Verdinexor (KPT-335) in water, the solubility of Verdinexor (KPT-335) in DMSO, the solubility of Verdinexor (KPT-335) in PBS buffer, the animal experiment (test) of Verdinexor (KPT-335), the cell expriment (test) of Verdinexor (KPT-335), the in vivo, in vitro and clinical trial test of Verdinexor (KPT-335), the EC50, IC50,and affinity,of Verdinexor (KPT-335), For the detailed information of Verdinexor (KPT-335), the solubility of Verdinexor (KPT-335) in water, the solubility of Verdinexor (KPT-335) in DMSO, the solubility of Verdinexor (KPT-335) in PBS buffer, the animal experiment (test) of Verdinexor (KPT-335), the cell expriment (test) of Verdinexor (KPT-335), the in vivo, in vitro and clinical trial test of Verdinexor (KPT-335), the EC50, IC50,and affinity,of Verdinexor (KPT-335), Please contact DC Chemicals.
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