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YKL-06-061
DC10778  (CAS:2172617-15-9 )
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100mg USD 550 In stock
250mg USD 950 In stock
1g USD 1900 In stock
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Fields of Application :
YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.
CAS Number: 2172617-15-9
Purity:

>98%

Molecular Weight: 527.3
Molecular Formula: C30H37N7O2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: YKL-06-061; YKL06-061; YKL 06-061; YKL-06061; YKL06061; YKL 06061
Chemical Name: 1-Cyclobutyl-3-(2,6-dimethylphenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
Storage: 4 Degree for 1 year, -20 degree for more than 2 years
Note: Products for research use only, not for human use
Description:
YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor. Salt-inducible kinases (SIKs) are related to the metabolic regulator AMP-activated protein kinase (AMPK). Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification. Pharmacologic inhibition of SIK sends HDAC4 to the nucleus and inhibits the calcification process in VSMCs, aortic rings, and in vivo In the cytoplasm, HDAC4 binds and its activity depends on the adaptor protein ENIGMA (Pdlim7) to promote vascular calcification.
References:
O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C
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