YKL-06-061|cas2172617-15-9 |SIK inhibitor-DC10778

YKL-06-061

DC10778 (CAS:2172617-15-9)

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Size	Price	Availability
100mg	USD 550	In stock
250mg	USD 950	In stock
1g	USD 1900	In stock

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Fields of Application :
YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.

CAS Number:	2172617-15-9
Purity:	>98%
Molecular Weight:	527.3
Molecular Formula:	C30H37N7O2

Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)

Synonyms:	YKL-06-061; YKL06-061; YKL 06-061; YKL-06061; YKL06061; YKL 06061
Chemical Name:	1-Cyclobutyl-3-(2,6-dimethylphenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
Storage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Note: Products for research use only, not for human use

Description:
YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor. Salt-inducible kinases (SIKs) are related to the metabolic regulator AMP-activated protein kinase (AMPK). Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification. Pharmacologic inhibition of SIK sends HDAC4 to the nucleus and inhibits the calcification process in VSMCs, aortic rings, and in vivo In the cytoplasm, HDAC4 binds and its activity depends on the adaptor protein ENIGMA (Pdlim7) to promote vascular calcification.

References:
O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C