gamma-secretase modulator 1 hydrochloride

  Cat. No.:  DC28074  
gamma-secretase modulator 1 hydrochloride
Chemical Structure
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Field of application
gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
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Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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MSDS
TITLE DOWNLOAD
MSDS_12130_DC28074
COA
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Cat. No. Product name Field of application
DC28676 Aβ42-IN-1 free base Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.
DC28675 Aβ42-IN-1 Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50 value of 0.091 µM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
DC28074 gamma-secretase modulator 1 hydrochloride gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
DC11615 γ-secretase modulator 14a A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM.