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lexibulin (CYT997)
DC5134  (CAS:917111-44-5)
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100mg USD 475 In stock
250mg USD 950 In stock
1g USD 1900 In stock
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Fields of Application :
CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 1/2.
CAS Number: 917111-44-5
Purity:

>98%

Molecular Weight: 434.534
Molecular Formula: C24H30N6O2
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: CYT997; CYT-997; CYT 997lexibulin.
Chemical Name: N-Ethyl-N'-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]urea
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
lexibulin, also known as CYT997, is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the Formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.For the detailed information of lexibulin (CYT997), the solubility of lexibulin (CYT997) in water, the solubility of lexibulin (CYT997) in DMSO, the solubility of lexibulin (CYT997) in PBS buffer, the animal experiment (test) of lexibulin (CYT997), the cell expriment (test) of lexibulin (CYT997), the in vivo, in vitro and clinical trial test of lexibulin (CYT997), the EC50, IC50,and Affinity of lexibulin (CYT997), Please contact DC Chemicals.
References:
CCC[C@H](NC1=C(C)C=NC(C2=CC=C(NC(NCC)=O)C(OC)=C2)=N1)C3=CN=CC=C3
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