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tw-37
DC5005  (CAS:877877-35-5)
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Fields of Application :
TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 M, 1.11 M and 0.26 M, respectively.
CAS Number: 877877-35-5
Purity:

>98%

Molecular Weight: 573.7
Molecular Formula: C33H35NO6S
Quality Control: HPLCNMR LC/MS(Please contact us to get the QC report)
Synonyms: TW37,TW 37
Chemical Name:
Storage: 2 years -20C Powder, 2 weeks4C in DMSO,6 months-80C in DMSO
Note: Products for research use only, not for human use
Description:
TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 M, 1.11 M and 0.26 M, respectively. IC50 Value: 0.29 M (Ki for Bcl-2) Target: Bcl-2 Family in vitro: TW-37 shows significant anti-proliferative and pro-apoptotic effect in a de novo chemo-resistant WSU-DLCL2 lymphoma cell line and primary cells obtained from a lymphoma patient without effects on normal peripheral blood lymphocytes. TW-37 exhibits the inhibitory effect on both cell growth and cell death in endothelial cell with IC50 of approximately 1.8 M without effect on the fibroblasts exposed to the same concentration range as the endothelial cells. In addition, TW37 also shows the anti-proliferation effects in MCF-7, LNCaP, and SLK tumor cell lines with the same or lower concentration range than those required to inhibit endothelial cell growth. in vivo: TW-37 shows a maximum tolerated dose (MTD) of 40 mg/kg for three i.v. injections in severe combined immunodeficient (SCID) mice when given alone, and enhances tumor inhibitory effect of cyclophosphamide-doxorubicin-vincristine-prednisone (CHOP) regimen. TW-37, administrated by i.v. produces the antiangiogenic effect by decreasing the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis. The combination of TW-37 and MEK inhibitors synergistically block melanoma cell growth in mice by a significant reduction in tumor volume and tumor mass. For the detailed information of tw-37, the solubility of tw-37 in water, the solubility of tw-37 in DMSO, the solubility of tw-37 in PBS buffer, the animal experiment (test) of tw-37, the cell expriment (test) of tw-37, the in vivo, in vitro and clinical trial test of tw-37, the EC50, IC50,and Affinity of tw-37, Please contact DC Chemicals.
References:
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