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wp1066£¨STAT Inhibitor III£©
DC8244  (CAS:857064-38-1)
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Fields of Application :
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT.
CAS Number: 857064-38-1
Purity:

>98%

Molecular Weight: 356.2
Molecular Formula: C17H14BrN3O
Quality Control: HPLC¡¢NMR¡¢ LC/MS(Please contact us to get the QC report)
Synonyms: wp1066, wp 1066,wp-1066
Chemical Name: 3-?(6-?bromo-?2-?pyridinyl)-?2-?cyano-?N-?[(1S)-?1-?phenylethyl]-?2E-?propenamide
Storage: 2 years -20¡ãC Powder, 2 weeks4¡ãC in DMSO,6 months-80¡ãC in DMSO
Note: Products for research use only, not for human use
Description:
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 ¦ÌM.1 It also induces apoptosis in U87-MG (IC50 = 5.6 ¦ÌM) and U373-MG (IC50 = 3.7 ¦ÌM) cells.WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats. For the detailed information of wp1066£¨STAT Inhibitor III£©, the solubility of wp1066£¨STAT Inhibitor III£© in water, the solubility of wp1066£¨STAT Inhibitor III£© in DMSO, the solubility of wp1066£¨STAT Inhibitor III£© in PBS buffer, the animal experiment (test) of wp1066£¨STAT Inhibitor III£©, the cell expriment (test) of wp1066£¨STAT Inhibitor III£©, the in vivo, in vitro and clinical trial test of wp1066£¨STAT Inhibitor III£©, the EC50, IC50,and affinity,of wp1066£¨STAT Inhibitor III£©, For the detailed information of wp1066£¨STAT Inhibitor III£©, the solubility of wp1066£¨STAT Inhibitor III£© in water, the solubility of wp1066£¨STAT Inhibitor III£© in DMSO, the solubility of wp1066£¨STAT Inhibitor III£© in PBS buffer, the animal experiment (test) of wp1066£¨STAT Inhibitor III£©, the cell expriment (test) of wp1066£¨STAT Inhibitor III£©, the in vivo, in vitro and clinical trial test of wp1066£¨STAT Inhibitor III£©, the EC50, IC50,and affinity,of wp1066£¨STAT Inhibitor III£©, Please contact DC Chemicals.
References:
C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
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