Home > Inhibitors & Agonists > PI3K/Akt/mTOR > AMPK
Cat. No. Product name CAS No.
DC11599 PF-739

A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers.

1852452-14-2
DC11656 AMPK-Activator-13

A potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM).

1243184-62-4
DC7045 A-769662

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity.

844499-71-4
DC7047 AICAR (Acadesine)

Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3.

2627-69-2
DC11130 AMPK activator 991

AMPK activator 991 is an allosteric AMPK activator, activates non-phosphorylated Thr172 AMPK in vitro binds to α1β1γ1 and α2β1γ1 with Kd of 0.13 and 0.17 uM, respectively..

1219739-95-3
DC11129 AMPK activator SC4

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle.

1364692-88-5
DC10978 BAY-3827

BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK as tool compound to evaluate the therapeutic potential of AMPK inhibition in MYC-dependent tumors.

DC7115 Dorsomorphin dihydrochloride

Dorsomorphin 2Hcl (Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits ALK2, ALK3, and ALK 6 .

1219168-18-9
DC8182 Bempedoic Acid(ETC-1002;ESP-55016)

ETC-1002(ESP-55016) is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

738606-46-7
DC11634 EX-229

EX229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM

1219739-36-2
DC7705 HTH-01-015

HTH-01-015 is a selective inhibitor of NUAK1 kinase with an IC50 value of 100 nM.

1613724-42-7
DC11405 MK-3903

MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. generation of catalytically active enzyme.

1219737-12-8
DC12020 MK-8722

MK-8722 is a systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.

1394371-71-1
DC11466 PF-06409577

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

1467057-23-3
DC11146 PF-06885249

PF-06885249 (PF06885249) is a potent, direct AMPK activator with EC50 of 7.0 and 27 nM for α1β1γ1 and α2β1γ1, respectively.

1467059-70-6
DC9343 ZLN024 (hydrochloride)

ZLN024 Hcl is a novel AMPK allosteric activator; activated α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 uM. IC50 value: 1-2 uM (EC50) [1] Target: AMPK activator ZLN024 activated AMPK in L6 myotubes and stimulated glucose uptake and

723249-01-2
DC8296 Dorsomorphin(BML-275)

Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B

866405-64-3
DC29234 GSK621 (GSK 621;GSK-621)

GSK621 (GSK-621) is a potent, specific AMPK agonist (activator), induces cytotoxicity in AML (IC50=13-30 uM) but not in normal hematopoietic cells; GSK621 is more potent than A-769662 at inducing AMPK activation, as measured by the level of ACC phosphorylation, markedly increases phosphorylation at AMPKα T172 in AML cell lines (MOLM-14, HL-60, and OCI-AML3) and primary AML samples; cytotoxicity in AML cells from GSK621 involves the eIF2α/ATF4 signaling pathway that specifically results from mTORC1 activation,

1346607-05-3
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