Home > Inhibitors & Agonists > Apoptosis
Cat. No. Product name CAS No.
DC9368 (S)-Gossypol (acetic acid)

(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).

1189561-66-7
DCC-073 Gossypol-acetic acid

>98%,Standard References

12542-36-8
DCS-114 Embelin

>98%,Standard References

550-24-3
DC11708 Mitochonic Acid 35

A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.

1611470-23-5
DC11637 MPK-09

A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.

1431884-83-1
DC11613 Mcl1-IN-26

A novel potent, selective Mcl-1 inhibitor with IC50 of <3 nM in FRET assays.

2056238-04-9
DC11852 CTX-1

A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.

501935-96-2
DC11669 CB-002

A novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.

61034-15-9
DC11865 DS-5272

A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM.

1235575-97-9
DC11834 AM-6761

A potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties.

1584732-36-4
DC11836 AM-8735

A potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties.

1429386-01-5
DC11830 WK-298

A potent small molecule inhibitor that binds and disrupts the MDM2/MDMX-p53 interaction with IC50 of 0.19 uM and 19.7 uM, respectively..

1067654-70-9
DC11837 RO-5963

A potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively.

1416663-77-8
DC11725 BI-0252

A potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM.

1818291-27-8
DC11695 AT-IAP

A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively.

1403898-55-4
DC11727 RO-2468

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.

1360821-21-1
DC11728 RO-5353

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.

1360821-61-9
DC11620 RIPK2-IN-8

A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.

2141969-56-2
DC11835 AM-8553

A potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM.

1352064-70-0
DC11833 TDP-665759

A small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.

787632-66-0
DC11832 NU-8165

A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 16 uM..

849723-20-2
DC11831 NU-8231

A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay.

878022-36-7
Page 1 / Total 6 FirstPrevNextLastGoto