Home > Inhibitors & Agonists > Membrane Transporter/Ion Channel > CFTR
Cat. No. Product name CAS No.
DC10388 (R)-BPO-27

(R)-BPO-27 is a potent CFTR inhibitor with an IC50 of 4 nM

1415390-47-4
DC12003 Corr4A

A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..

421580-53-2
DC10387 BPO-27 racemat

BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.

1314873-02-3
DC7039 CFTR Inhibitor II Featured

CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells.

328541-79-3
DC10753 GLPG-1837(ABBV-974) Featured

GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.

1654725-02-6
DC11678 GLPG-2222

GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.

1918143-53-9
DC7172 IOWH-032

iOWH032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.

1191252-49-9
DC4128 Ivacaftor (VX-770) Featured

Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.

873054-44-5
DC9276 KM 11060 Featured

KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity.

774549-97-2
DC11096 Olacaftor

Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis..

1897384-89-2
DC7483 PPQ-102 Featured

PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.

931706-15-9
DC7100 CFTRinh 172 Featured

Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.

307510-92-5
DC7531 VX661 Featured

VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.

1152311-62-0
DC1059 Lumacaftor(vx-809,vx809) Featured

VX-809 is a CFTR modulator with EC50 of 0.1 μM.

936727-05-8
DC28157 PG01

PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (Ka of 0.3 μM). PG01 increases ΔF508-CFTR Cl- current after adding Forskolin.

853138-65-5
DC28703 GLPG-3221

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis.

2222264-64-2
DC28791 CFTR corrector 4

CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis.

1918142-34-3
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