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Cat. No. Product name CAS No.
DC10388 (R)-BPO-27

(R)-BPO-27 is a potent CFTR inhibitor with an IC50 of 4 nM

DC12003 Corr4A

A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..

DC10387 BPO-27 racemat

BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.

DC7039 CFTR Inhibitor II

CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells.

DC10753 GLPG-1837(ABBV-974)

GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.

DC11678 GLPG-2222

GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.

DC7172 IOWH-032

iOWH032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.

DC4128 Ivacaftor (VX-770)

Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.

DC9276 KM 11060

KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity.

DC11096 Olacaftor

Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis..

DC7483 PPQ-102

PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.

DC7100 CFTRinh 172

Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.

DC7531 VX661

VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.

DC1059 Lumacaftor(vx-809,vx809)

VX-809 is a CFTR modulator with EC50 of 0.1 μM.

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