Home > Inhibitors & Agonists > Immunology/Inflammation > Complement System
Cat. No. Product name CAS No.
DC11688 Avacopan Featured

Avacopan is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.

1346623-17-3
DC11082 Danicopan (ACH-4471) Featured

Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM.

1903768-17-1
DC9953 Leukadherin-1 Featured

Leukadherin-1 is a specific agonist of CR3 and the leukocyte surface integrin CD11b/CD18.

344897-95-6
DC28985 (Z)-Leukadherin-1

(Z)-Leukadherin-1 (ADH-503 free base) is an orally active and allosteric CD11b agonist. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses.

2055362-72-4
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