Home > Inhibitors & Agonists > Proteasome/Ubiquitin > Deubiquitinase (DUB)
Cat. No. Product name CAS No.
DC11488 USP7-IN-4

(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays.

2196243-57-7
DC11553 FT-827

A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).

1959537-86-0
DC10838 F1063-0967

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.

613225-56-2
DC11554 FT-671

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).

1959551-26-8
DC12495 GNE-6640

GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM).

2009273-67-8
DC11555 GNE-6776

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM .

2009273-71-4
DC12049 GSK2643943A

GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM.

DC10354 HBX 19818

HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM .

1426944-49-1
DC7610 LDN-57444

LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.

668467-91-2
DC10917 MF-094

MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM.

2241025-68-1
DC7468 ML-323

ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.

1572414-83-5
DC10091 ML364

ML364 is an USP2 inhibitor.xtracted from patent WO 2016134026 A1, compound example 10G.

1991986-30-1
DC10001 NSC632839

NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively.

157654-67-6
DC8319 Spautin 1

Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes.

1262888-28-7
DC10298 Ubiquitin Isopeptidase Inhibitor I, G5

Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

108477-18-5
DC11509 USP25 and 28 inhibitor AZ-2

USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.

2165322-95-0
DC7525 USP7-USP47 inhibitor

USP7/USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 uM(USP7) and 1.0 uM(USP47).

1247825-37-1
DC10642 VLX1570

VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.

1431280-51-1
DC11876 XL 188

XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.

DC11506 USP25 and 28 inhibitor AZ-1

USP25 and 28 inhibitor AZ-1 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.7/0.6 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.)

2165322-94-9
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