Home > Inhibitors & Agonists > GPCR > Endothelin Receptor
Cat. No. Product name CAS No.
DCAPI1496 Ambrisentan

A nonpeptide endothelin ETA receptor antagonist. Antihypertensive.

DC8191 Sparsentan(PS433540)

acting as both an Endothelin Receptor Antagonist (ERA) and Angiotensin Receptor Blocker (ARB).

DC11513 Aprocitentan (ACT-132577)

Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.

DC10018 Atrasentan hydrochloride

Atrasentan Hcl(A-147627) is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.

DC9436 Avosentan

Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.

DC9437 Bosentan

Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.

DCAPI1483 Bosentan Hydrate

Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

DC8392 BQ-123

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

DC12498 S-Darusentan

Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries.

DC1012 Macitentan (Actelion-1,ACT-064992)

macitentan (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM.

DC9666 Ro 46-2005

Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

DC4108 Sitaxentan sodium

Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.

DC9435 Zibotentan(ZD4054)

Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).

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