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Cat. No. Product name CAS No.
DC11931 Alofanib Featured

Alofanib ((RPT-835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM

1612888-66-0
DC1075 AZD4547 Featured

AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively.

1035270-39-3
DC5194 NVP-BGJ398(Infigratinib) Featured

BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.

872511-34-7
DC10092 BLU554(Fisogatinib) Featured

BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.

1707289-21-1
DC8280 BLU-9931 Featured

BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM).

1538604-68-0
DC8418 CH5183284 (Debio-1347) Featured

CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1.

1265229-25-1
DC10559 Derazantinib (ARQ 087) Featured

Derazantinib (Derazantinib) is an ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 4.5, 1.8, and 4.5 nM, respectively.

1234356-69-4
DC4157 Dovitinib (TKI258, CHIR258) Featured

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

405169-16-6
DC10313 Dovitinib lactate

Dovitinib(CHIR-258; TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) with an IC50 of 5 nM.

692737-80-7
DC11387 Erdafitinib Featured

Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1-4 with IC50 values of 1.2, 2.5, 3.0 and 5.7nM, respectively.

1346242-81-6
DC10128 FGF401( Roblitinib) Featured

FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.

1708971-55-4
DC9933 FGFR4-IN-1

FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.

1708971-72-5
DC8330 FIIN-2 Featured

FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor.

1633044-56-0
DC9642 FIIN-3 Featured

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor.

1637735-84-2
DC10033 H3B-6527 Featured

H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.

1702259-66-2
DC7019 LY-2874455 Featured

LY2874455 is a novel and potent FGF/FGFR inhibitor.

1254473-64-7
DC9945 NSC-12

NSC12 is a PTX3-derived anti-FGF small molecule, inhibits FGF-dependent tumor growth, angiogenesis, and metastases,acts as a small-molecule FGF trap in cancer therapy.

102586-30-1
DC10068 PD166866 Featured

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.

192705-79-6
DC2054 PD-173074 Featured

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

219580-11-7
DC10641 PRN1371

PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively.

1802929-43-6
DC7508 SU 5402 Featured

SU5402(SU-5402; SU5402) is potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively).

215543-92-3
DC10271 SUN11602 Featured

SUN11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor.

704869-38-5
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