Home > Inhibitors & Agonists > NF-κB Pathway > IκB kinase (IKK)
Cat. No. Product name CAS No.
DC11927 iNUB

A small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.

352336-00-6
DC8658 AZD3264

AZD 3264 is an IkB-kinase IKK2 Inhibitor, IKK2 has been identified as one of the novel pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.

1609281-86-8
DC11960 BI605906

BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.

960293-88-3
DC7158 IKK-16 HCl Featured

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

1186195-62-9
DC9485 IKK-16(free base) Featured

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

873225-46-8
DC9484 IKK-2 inhibitor VIII

IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.

406209-26-5
DC7802 IKK(epsilon)-IN-1 (IKKE-IN-1) Featured

IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.

1292310-49-6
DC8770 IMD-0354 Featured

IMD-0354 is a synthetic selective NF-kB inhibitor.

978-62-1
DC8065 LY2409881 trihydrochloride Featured

LY2409881 is a novel inhibitor of IκB kinase β (IKK2).

946518-60-1
DC7969 PS-1145

PS-1145 has been shown to be an IKK (IKB kinase) inhibitor.

431898-65-6
DC7159 TPCA-1

TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays>22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes.

507475-17-4
DC7760 WS3 Featured

WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).

1421227-52-2
DC7759 WS6 Featured

WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

1421227-53-3
DC8761 BMS-345541 Featured

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.

547757-23-3
DC28732 BAY-985

BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy.

2409479-29-2
DC28733 (Rac)-BAY-985

(Rac)-BAY-985 (Compound Example 100.01) is a potent, ATP-competitive and selective TBK1 inhibitor with an IC50 of 1.5 nM. Antitumor efficacy.

2101925-20-4
DC28821 HPN-01

HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2.

928655-63-4
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