Home > Inhibitors & Agonists > Nuclear Receptor/Transcription Factor > Keap1-Nrf2
Cat. No. Product name CAS No.
DCL-047 Sulforaphane

>98%,Standard References

4478-93-7
DC11985 PSTC

A novel potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity).

DC4135 Bardoxolone methyl

Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class.

218600-53-4
DC11499 BPK-29

BPK-29 is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.

2143467-62-1
DC10913 Brusatol

Brusatol (NSC 172924, (+)-Brusatol) is a quassinoid extracted from Brucea Esters, can inhibit HIF-1 signaling pathway, also is a potent Nrf2 inhibitor.

14907-98-3
DCAPI1084 Ezetimibe (Zetia) Featured

Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

163222-33-1
DC10282 ML385 Featured

ML385 is a novel and specific NRF2 inhibitor.

846557-71-9
DC8198 RTA-408

RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB.

1474034-05-3
DC28273 ML334

ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.

1432500-66-7
DC28729 Ezetimibe ketone

Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor.

191330-56-0
DC40359 Keap1-Nrf2-IN-1

Keap1-Nrf2-IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models.

2232112-72-8
DC40751 CBR-470-2

CBR-470-2, a glycine-substituted analog, and can activate NRF2 signaling. CBR-470-2 can be used for modulation glycolysis.

2416095-00-4
DC40756 CBR-470-1

CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade.

2416095-06-0
DC41378 (S)-Falcarinol

(S)-Falcarinol ((S)-Panaxynol), one of the major polyacetylenes isolated from Panax ginseng, has antitumor activity. (S)-Falcarinol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. (S)-Falcarinol is a potent Nrf2 activator.

81203-57-8
DC41436 Toralactone

Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism.

41743-74-2
DC41778 TAT-14

TAT-14 is a 14-mer peptide that acts as?Nrf2?activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1.

1362661-34-4
DC41779 TAT-14 TFA

TAT-14 TFA?is a 14-mer peptide that acts as?Nrf2?activator with an anti-inflammatory effect. TAT-14 TFA has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1.

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