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Cat. No. Product name CAS No.
DC7113 CZC-25146 Featured

CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively.

1191911-26-8
DC8082 CZC-54252 Featured

CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively).

1191911-27-9
DC7418 GNE-0877

GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.

1374828-69-9
DC7419 GNE-7915 Featured

GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki).

1351761-44-8
DC7629 GNE-9605 Featured

GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor

1536200-31-3
DC7852 LRRK2 inhibitor GSK2578215A Featured

GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.

1285515-21-0
DC8379 JH-II-127 Featured

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.

1700693-08-8
DC11440 LRRK2 inhibitor 18

LRRK2 inhibitor 18(Compound 18) is a potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 4.1 nM.

1459257-24-9
DC8237 LRRK2-IN-1 Featured

LRRK2-IN-1 inhibits both wild-type and G2019S mutant LRRK2 kinase activity with IC50 values of 13 nM and 6 nM , respectively with 0.1 mM ATP in the assay.

1234480-84-2
DC10360 MLi-2

MLi-2 is an a potent, highly selective, orally available, brain penetrant inhibitor of LRRK2 with an IC50 of 0.76 nM.

1627091-47-7
DC7971 PF-06447475 Featured

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.

1527473-33-1
DC11288 PF-06454589 Featured

PF-06454589 is a potent and selective LRRK2 inhibitor.

1527473-30-8
DC9496 HG-10-102-01 Featured

HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM)

1351758-81-0
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