Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > Monopolar Spindle 1 (Mps1/TTK)
Cat. No. Product name CAS No.
DC11704 CFI-401870

A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM.

1599460-95-3
DC11677 CCT-271850

A potent, selective, orally bioavailable Mps1 kinase inhibitor with IC50 of 11 nM.

1578244-34-4
DC7072 AZ3146

AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM); less potent to FAK, JNK1, JNK2, and Kit.

1124329-14-1
DC9679 BAY1217389

BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity.

1554458-53-5
DC7470 MPI-0479605

MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.

1246529-32-7
DC8119 Mps1-IN-2

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.

1228817-38-6
DC5087 Mps1-IN-1

Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.

1125593-20-5
DC9740 CFI402257

CFI-402257 is a highly potent and selective TTK (threonine tyrosine kinase) Inhibitor ((TTK Ki = 0.1 nM) with potential anticancer activity.

1610759-22-2
DC7866 NMS-P715

NMS-P715 is the first selective, ATP-competitive and orally bioavailable MPS1 small-molecule inhibitor(IC50=8 nM); selectively reduces cancer cell proliferation, leaving normal cells almost unaffected.

1202055-32-0
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