Home > Inhibitors & Agonists > GPCR > Neurokinin Receptor
Cat. No. Product name CAS No.
DC11629 NK1-IN-9

A potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM).

1100211-97-9
DC11755 L-732138

A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.

148451-96-1
DC11756 SR 140333

A potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM.

153050-21-6
DCAPI1094 Fosaprepitant

Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

172673-20-0
DC4201 Fosaprepitant dimeglumine

Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

265121-04-8
DC9519 Maropitant

Maropitant is a neurokinin (NK1) receptor antagonist.

147116-67-4
DC9520 NKP608

NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

177707-12-9
DC7245 SB 222200

SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier.

174635-69-9
DC6906 Aprepitant (MK-0869, L-754030) Featured

Substance P antagonists (SPA).

170729-80-3
DC8614 Rolapitant Featured

Rolapitant (SCH619734) is a potent, selective and orally active neurokinin NK1 receptor antagonist with a Ki of 0.66 nM.

552292-08-7
DC28435 Orvepitant maleate

Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.

579475-24-4
DC28971 Osanetant

Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.

160492-56-8
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