Home > Inhibitors & Agonists > NF-κB Pathway
Cat. No. Product name CAS No.
DCL-027 Lipoic acid

>98%,Standard References

62-46-4
DC11927 iNUB

A small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.

352336-00-6
DC11926 NDMC101

A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.

1308631-40-4
DC11925 ABD328

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.

1055896-19-9
DC11182 AM-0216

AM-0216 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent.

1202761-92-9
DC11181 AM-0561

AM-0561 (AM0561) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 0.3 nM..

1202764-63-3
DC11180 Amgen 16

Amgen16 is a highly potent inhibitor of NF-κB inducing Kinase (NIK), example 294 in patent WO 2009158011 A1..

1202764-61-1
DC8658 AZD3264

AZD 3264 is an IkB-kinase IKK2 Inhibitor, IKK2 has been identified as one of the novel pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.

1609281-86-8
DC7869 BAY11-7082 Featured

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. Also inhibiting components of the ubiquitin system.

19542-67-7
DC8038 Bay 11-7085 Featured

BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with an IC50 value of 10 μM.

196309-76-9
DC11960 BI605906

BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK.

960293-88-3
DC8827 Didox Featured

Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers.

69839-83-4
DC10939 Edasalonexent

Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA).

1204317-86-1
DC8872 Iguratimod Featured

Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity.

123663-49-0
DC7158 IKK-16 HCl Featured

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

1186195-62-9
DC9485 IKK-16(free base) Featured

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

873225-46-8
DC9484 IKK-2 inhibitor VIII

IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.

406209-26-5
DC7802 IKK(epsilon)-IN-1 (IKKE-IN-1) Featured

IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.

1292310-49-6
DC8770 IMD-0354 Featured

IMD-0354 is a synthetic selective NF-kB inhibitor.

978-62-1
DC10768 IT 901 Featured

IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro.

1584121-99-2
DC7741 JSH-23 Featured

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.

749886-87-1
DC8065 LY2409881 trihydrochloride Featured

LY2409881 is a novel inhibitor of IκB kinase β (IKK2).

946518-60-1
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