Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > PARP
Cat. No. Product name CAS No.
DC11779 TNKS-IN-41

A highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.

1584646-59-2
DC7046 A-966492

A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.

934162-61-5
DC5106 AG14361 Featured

AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.

328543-09-5
DC7926 AZ-6102 Featured

AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells.

1645286-75-4
DC10056 AZ9482

AZ9482, a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine.

1825345-33-2
DC1037 AZD2461 Featured

AZD2461 is a novel PARP inhibitor with potential to bypass Pgp-mediated resistance to Olaparib.

1174043-16-3
DC8571 BGP-15 Featured

BGP-15 is a PARP inhibitor and insulin sensitizer.

66611-37-8
DC8453 Talazoparib(BMN-673)tosylate Featured

BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.

1373431-65-2
DC2008 Talazoparib(BMN-673) Featured

BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.

1207456-01-6
DC8452 BMN-673 8R,9S

BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM(PARP1). It does not inhibit PARG and is highly sensitive to PTEN mutation.

1207456-00-5
DC7378 BSI-201

BSI-201 (Iniparib; NSC-746045) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).

160003-66-7
DC9983 E-7449 Featured

E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2; enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors.

1140964-99-3
DC8222 G007-LK Featured

G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor.

1380672-07-0
DC11504 GeA-69 Featured

GeA-69(GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays.

2143475-98-1
DC11080 JPI-289

JPI-289 (JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.

1449233-60-6
DC7169 JW55 Featured

JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively.

664993-53-7
DC7871 KCL-440

KCL-440 is a a new poly(ADP-ribose) polymerase- PARP inhibitor.

651029-09-3
DC11141 ME0328 Featured

ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.

1445251-22-8
DC4179 Niraparib(MK4827) free base Featured

MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity.

1038915-60-4
DC9862 Niraparib(MK4827) hydrochloride Featured

MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity.

1038915-64-8
DC9576 Niraparib(MK-4827) tosylate Featured

MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.

1038915-73-9
DC8659 MN-64 Featured

MN-64 is a inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

92831-11-3
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