Home > PROTACs > PROTAC
Cat. No. Product name CAS No.
DC11564 CDK9-PROTAC

A heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.

2118356-96-8
DC11590 CM11

A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation.

DC11867 TBK1 PROTAC 1

A novel potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.

2052306-13-3
DC11562 Sirt2-PROTAC-1

A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM)..

2098487-75-1
DC12702 A1874 Featured

A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells).

2064292-12-0
DC10334 ARV-771 Featured

ARV-771 is a potent bromodomain and extra-terminal (BET) proteins degrader with Kd values of 4.7, 7.6, 7.6 nM against bromodomain 2, 3 and 4, respectively.

1949837-12-0
DC12024 ARV-825 Featured

ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.

1818885-28-7
DC11566 BETd-260 Featured

BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

2093388-62-4
DC11567 BETd-260 trifluoroacetate

BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

2140289-21-8
DC10997 BRD4 degrader AT1

BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.

2098836-45-2
DC12380 BSJ-03-123 Featured

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.

2361493-16-3
DC11065 BTK PROTAC 10

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.

DC11064 BTK PROTAC 9

BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK.

DC11679 CCT-367766

CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells..

2229856-58-8
DC12023 dBET1 Featured

dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM.

1799711-21-9
DC21893 dBET57 Featured

dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2..

1883863-52-2
DC12022 dBET6 Featured

dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM, and has antitumor activity.

1950634-92-0
DC11589 dBRD9

dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

2170679-45-3
DC10932 HDAC6 degrader 9c

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.

2235382-05-3
DC21351 MS4078 Featured

MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM).

2229036-62-6
DC21360 MZ1 Featured

MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.

1797406-69-9
DC11040 QCA570

QCA570 is a novel, highly potent efficacious BET degrader (PROTAC).

2207569-08-0
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