Home > PROTACs > PROTAC
Cat. No. Product name CAS No.
DC11564 CDK9-PROTAC

A heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.

2118356-96-8
DC11590 CM11

A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation.

DC11867 TBK1 PROTAC 1

A novel potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.

2052306-13-3
DC11562 Sirt2-PROTAC-1

A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM)..

2098487-75-1
DC11566 BETd-260

BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

2093388-62-4
DC11567 BETd-260 trifluoroacetate

BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

2140289-21-8
DC10997 BRD4 degrader AT1

BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.

2098836-45-2
DC12380 BSJ-03-123

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.

2361493-16-3
DC11065 BTK PROTAC 10

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.

DC11064 BTK PROTAC 9

BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK.

DC11679 CCT-367766

CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells..

2229856-58-8
DC12023 dBET1

dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM.

1799711-21-9
DC12022 dBET6

dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM, and has antitumor activity.

1950634-92-0
DC11589 dBRD9

dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

2170679-45-3
DC10932 HDAC6 degrader 9c

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.

2235382-05-3
DC11040 QCA570

QCA570 is a novel, highly potent efficacious BET degrader (PROTAC).

2207569-08-0
DC11584 SNIPER(ABL)-062

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.

2140260-89-3
DC11749 THAL-SNS-032

THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

2139287-33-3
DC11002 Gefitinib-based PROTAC 3

2230821-27-7
DC11001 Foretinib-Based PROTAC 7

2230821-68-6
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