Home > Inhibitors & Agonists > TGF-beta/Smad > TGF beta Receptor (TGFBR)
Cat. No. Product name CAS No.
DC8020 A77-01

A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.

607737-87-1
DC7286 A83-01

A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).

909910-43-6
DC7643 DMH1

DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.

1206711-16-1
DC8342 EW-7197

EW-7197 is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy.

1352608-82-2
DC7980 GW6604

GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity.

452342-37-9
DC7146 GW788388

GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.

452342-67-5
DC8028 ITD-1

ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells.

1099644-42-4
DC7742 K02288

K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.

1431985-92-0
DC7914 LDN-214117

LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).

1627503-67-6
DC7189 LY-2109761

LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.

700874-71-1
DC6306 LY2157299(Galunisertib)

LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.

700874-72-2
DC10675 LY3200882

LY3200882 is a novel, highly selective TGFβRI small molecule inhibitor.

1898283-02-7
DC7587 ML347

ML347 is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM

1062368-49-3
DC8022 R-268712

Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 = 2.5 nM). Exhibits ~ 5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Orally bioavailable. For the detailed information of R-268712, the solubility of R-268712 in water, the solubility of R-268712 in DMSO, the solubility of R-268712 in PBS buffer, the animal experiment (test) of R-268712, the cell expriment (test) of R-268712, the in vivo, in vitro and clinical trial test of R-268712, the EC50, IC50,and affinity,of R-268712, Please contact DC Chemicals..

879487-87-3
DC7259 Repsox(ALK5 Inhibitor II)

RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.

446859-33-2
DC5189 SB-431542

SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.

301836-41-9
DC6312 SB525334

SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.

356559-20-1
DC7739 SD-208

SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM)

627536-09-8
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