Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > Topoisomerase
Cat. No. Product name CAS No.
DC11932 GPX-150

A doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM.

236095-29-7
DC8923 AS-1413(Amonafide)

Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.

69408-81-7
DC11470 Belotecan hydrochloride(CKD-602) Featured

Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative.

213819-48-8
DC7905 beta-Lapachone (ARQ-501, CO-501) Featured

Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.

4707-32-8
DC9832 Betulinic acid Featured

Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M.

472-15-1
DC6701 Camptothecine

Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.

7689-03-4
DCAPI1566 Cytarabine hydrochloride

Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent which binds to topoisomerase I resulting in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinof

69-74-9
DC4188 Doxorubicin hydrochloride Featured

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

25316-40-9
DC10410 Ellipticine hydrochloride Featured

Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

5081-48-1
DC8325 Ellipticine Featured

Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.

519-23-3
DC2102 Etoposide 4'-Phosphate

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

117091-64-2
DC7131 GENZ-644282

Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity(IC50=1.2 nM).

529488-28-6
DC8111 Idarubicin hydrochloride Featured

Idarubicin Hcl is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor.

57852-57-0
DC4153 Irinotecan hydrochloride trihydrate

Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.

136572-09-3
DC8934 Irinotecan Featured

Irinotecan(CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.

97682-44-5
DC5905 SN-38(NK-012)

SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

86639-52-3
DC8852 SW-044248 Featured

SW-044248 is a Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines.

522650-83-5
DC8536 TAS-103 2HCl Featured

TAS-103 2Hcl(BMS-247615 2Hcl) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).

174634-09-4
DC7898 TAS-103(BMS247615)

TAS-103(BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).

174634-08-3
DC7530 Voreloxin Featured

Voreloxin(SNS-595; AG 7352) is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II.

175414-77-4
DC5184 Epirubicin HCl (4'-epidoxorubicin) Featured

Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.

56390-09-1
DC28079 RPR121056

RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE.

181467-56-1
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