Home > Inhibitors & Agonists > Tyrosine Kinase > Trk Receptor
Cat. No. Product name CAS No.
DC10215 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).

38183-03-8
DC8029 ANA-12

ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.

219766-25-3
DC10448 Belizatinib(TSR-011)

Belizatinib(TSR-011) is an orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential antineoplastic activity.

1357920-84-3
DC8300 Entrectinib (RXDX-101)

Entrectinib (RXDX-101), a potent and selective small molecule inhibitor of TrkA/B/C, ROS1, and ALK kinases, has demonstrated early clinical activity when orally administered intermittently under fasting conditions.

1108743-60-7
DC7145 GW441756

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.

504433-23-2
DC9837 Larotrectinib (LOXO-101 sulfate)

LOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.

1223405-08-0
DC11448 LOXO 195(Selitrectinib)

LOXO-195 is a next-generation TRK kinase (TKI) inhibitor, with IC50s of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC respectively.

2097002-61-2
DC10631 PF-06273340

PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively.

1402438-74-7
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