Dexrazoxane hydrochloride is a cardioprotectant. Studies have shown that usage of this drug before anthracycline chemotherapy in pediatric patients with AML may improve cardiac function indices such as ejection fraction and shortening fraction. Adding dexrazoxane to doxorubicin in adjuvant therapy patients may lead to higher rates of bone marrow suppression, more febrile neutropenia events, and dose reductions.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.