DC Chemicals
-Chemicals for Life Science
-competitive price and high quality!www.dcchemicals.com
COA of BRD7586
Description:
BRD-7586(BRD 7586) is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2 µM and 5.7 µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci.
Chemical Information
| Catalog | Featured products |
|---|---|
| Purity of current batch | >98% |
| CAS | 895460-70-5 |
| Molecular Weight (MW) | 407.90 |
| Molecular Formula | C17H14ClN3O3S2 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Reference:
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules-Donghyun Lim, Qingxuan Zhou, etl. Nature Cell Biology volume 24, pages1766–1775 (2022)Cite this article