CID-078 is an orally bioavailable macrocyclic compound that binds to the RxL groove of both cyclin A and cyclin B. By engaging this conserved docking site, it blocks their interactions with multiple components of the cell cycle machinery. More specifically, this agent disrupts HP-RxL motif‑mediated protein–protein interactions within the cyclin A2/CDK2‑E2F1 and cyclin B1/CDK1‑MYT1 complexes. The resulting interference leads to cell cycle arrest and triggers apoptotic cell death in tumor cells.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.