113-AA-C8C14 is a leading β-hydroxy thioether-derived ionizable lipid that forms lipid nanoparticles (LNPs) for highly efficient, spleen-tropic mRNA delivery. Its key function is to enable targeted gene expression in the spleen, achieving a 57-fold increase in mRNA delivery compared to benchmark formulations. This capability allows it to efficiently engineer chimeric antigen receptor (CAR) T cells directly in vivo. Specifically, when loaded with CD19-CAR mRNA, 113-AA-C8C14 LNPs generate 2.7 times more CAR T cells, enhance effector cytokine production, and significantly inhibit tumor growth in mouse models, demonstrating great potential for in vivo CAR T cell therapy.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.