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COA of MK-0752

Description:

MK-0752 is a moderately potent γ-secretase inhibitor, it is used as a head group of MK16 which is a a novel blood-brain barrier (BBB)-crossing lipid nanoparticle (BLNP) platform developed for efficient mRNA delivery to the central nervous system (CNS).

Chemical Information

Catalog Featured products
Purity of current batch >98%
CAS 471905-41-6
Molecular Weight (MW) 442.9
Molecular Formula C21H21ClF2O4S
Storage 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Handling:

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Reference:

Wang, C., Xue, Y., Markovic, T.et al. Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nat. Mater. (2025).