MCH-1623 is a nucleoside analog-derived, RNA-dependent RNA polymerase (RdRP) inhibitor. MCH-1623 interferes with viral RNA synthesis and exhibits broad-spectrum antiviral activity. MCH-1623 effectively inhibits the replication of vesicular stomatitis virus (VSV), influenza A virus (H1N1-PR8), human coronavirus OC43, human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). Administered via inhalation, MCH-1623 exerts significant in vivo activity in mice, reducing pulmonary viral load and IL-6 levels, alleviating pulmonary tissue erythema, and significantly improving the survival rate of mice infected with lethal influenza virus. MCH-1623 can be used to investigate the infection mechanisms of various RNA viruses and for antiviral drug research.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.