2N12B Datasheet DC Chemicals
Description 2N12B is a redox-responsive cationic lipid (pKa = 6.5) designed for siRNA delivery. Its LNPs mediate robust VEGFA knockdown in both cultured retinal cells and ex vivo mouse retina, while functionally impairing HUVEC motility. When administered in retinopathy models, the nanoparticles alleviate disease hallmarks including abnormal vessel growth and retinal vascular leakage.
Cat.No DC67461
Name 2N12B

Chemical Properties

CAS 3067164-96-6
Formula C51H97N3O8S3
MW 976.5
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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