Simotaxel Datasheet DC Chemicals

Description	Simotaxel (MST 997) is an orally active derivative of the taxane class. Simotaxel binds to β-tubulin and promotes tubulin polymerization (EC₅₀ = 0.9 μM), inhibits tubulin depolymerization, and causes cell cycle arrest at the G₂-M phase. Simotaxel disrupts the formation of the mitotic spindle and triggers the caspase-dependent apoptotic pathway (apoptosis). Simotaxel has inhibitory effects on Paclitaxel sensitive cell lines and overcomes drug resistance. Simotaxel can be used to study Paclitaxel / Docetaxel resistant solid tumors.
Cat.No	DC81539
Name	Simotaxel

Chemical Properties

CAS	781-43-1
Formula	C16H14
MW	206.28
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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