ISM012-042 Datasheet DC Chemicals

Description	ISM012-042 is an orally active, selective inhibitor of PHD1 and PHD2, with IC50 values of 1.9 nM and 2.5 nM, respectively. ISM012-042 stabilizes HIF1α protein in intestinal epithelial cells, thereby activating gene transcription programs associated with mucus production, tight junction formation, anti-inflammatory mediator generation and wound healing, which fundamentally promotes mucosal barrier repair and regulates intestinal immunity. ISM012-042 can be used for the research of inflammatory bowel disease.
Cat.No	DC60936
Name	ISM012-042

Chemical Properties

CAS	2924181-80-4
Formula	C26H28N6O4
MW	488.54
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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