Lipid 114 Datasheet DC Chemicals
Description Lipid 114 (pKa ~6.8) is an ionizable cationic lipid optimized for siRNA delivery via LNPs, demonstrating predominant hepatic accumulation with secondary renal uptake in murine models. When formulated with IL-1β-targeting siRNA, these LNPs effectively suppress pro-inflammatory cytokine expression in both macrophage cell lines and primary cells in a dose-dependent manner. In LPS/galactosamine-induced acute liver failure models, the therapeutic LNPs significantly reduce IL-1β levels in target organs while attenuating hepatic inflammation and injury markers.
Cat.No DC67453
Name Lipid 114

Chemical Properties

CAS
Formula C95H186N4O10
MW 1544.5
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
Tel: +86-21-58447131
Fax: +86-21-61642470

Email:
sales@dcchemicals.com
order@dcchemicals.com

Website:
www.dcchemicals.com