L2 is a redox-responsive lipid engineered for ultra-potent siRNA delivery. With shorter hexyl (C6) tails and a carbamate linker, it demonstrates the fastest biodegradation (liver half-life: 2.6 days) among tested lipids. L2 achieves >80% FVII gene knockdown at just 0.01 mg/kg—surpassing both L1 and MC3 in siRNA potency. Its higher apparent pKa (6.90) enhances endosomal disruption, correlating with strong in vitro hEPO expression. While slightly less effective for mRNA than L1, L2’s unmatched siRNA silencing efficiency, rapid cytosolic self-immolation, and low cytotoxicity position it as a leading candidate for RNAi therapeutics targeting hepatic diseases.
Cat.No
DC67543
Name
ATX L2
Chemical Properties
CAS
Formula
C42H82O6N2S2
MW
775.25
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
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