This study investigates neuroblastoma with additional insights into medulloblastoma, revealing that the small-molecule compound FLIX5 exhibits broad-spectrum cytotoxicity against both tumor types, primarily by inducing apoptosis. Under conditions of impaired mitochondrial function, FLIX5 was found to enhance cholesterol dependency in neuroblastoma cells. Furthermore, FLIX5 demonstrated synergistic anticancer effects when combined with the conventional chemotherapeutic agent vincristine in both cellular and organoid models. Using techniques including protein solubility profiling, molecular docking predictions, and cellular thermal shift assays, the study identified EPLIN (Epithelial Protein Lost In Neoplasm)—a previously unexplored drug target—as the binding target of FLIX5. EPLIN is involved in multiple cellular processes such as cholesterol uptake and mitochondrial function. These findings offer a novel therapeutic target and strategy for treating aggressive pediatric cancers with MYCN amplification, with potential implications for eradicating drug-resistant dormant tumor cells and expanding treatment indications.
Cat.No
DC67585
Name
FLIX5
Chemical Properties
CAS
Formula
MW
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
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