Lipid 113-AA-C8C14 Datasheet DC Chemicals

Description	113-AA-C8C14 is a leading β-hydroxy thioether-derived ionizable lipid that forms lipid nanoparticles (LNPs) for highly efficient, spleen-tropic mRNA delivery. Its key function is to enable targeted gene expression in the spleen, achieving a 57-fold increase in mRNA delivery compared to benchmark formulations. This capability allows it to efficiently engineer chimeric antigen receptor (CAR) T cells directly in vivo. Specifically, when loaded with CD19-CAR mRNA, 113-AA-C8C14 LNPs generate 2.7 times more CAR T cells, enhance effector cytokine production, and significantly inhibit tumor growth in mouse models, demonstrating great potential for in vivo CAR T cell therapy.
Cat.No	DC68142
Name	Lipid 113-AA-C8C14

Chemical Properties

CAS
Formula
MW
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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