GSK321 Datasheet DC Chemicals
Description GSK321 is a potent and selective IDH1 mutant inhibitor. GSK321 potently inhibited intracellular 2-HG production in HT-1080 cells, with a half-maximal effective concentration (EC50) of 85 nM by LC/MS/MS analysis. The inhibition of mutant IDH1 by GSK321 overcomes the pathognomonic differentiation block of AML cells and induces myeloid differentiation of IDH1 mutant cells at the level of leukemic blasts and more stem-like cells.
Cat.No DC32526
Name GSK321

Chemical Properties

CAS 1816331-63-1
Formula C28H28FN5O3
MW 501.5624
Storage

References

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