Description
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma.
Cat.No
A026
Name
Mepolizumab Biosimilar(Anti-IL-5 Reference Antibody)
Chemical Properties
CAS
196078-29-2
Synonyms
ImmunoglobulinG1, anti-(human interleukin 5) (human-mouse monoclonal SB-240563 g1-chain),disulfide with human-mouse monoclonal SB-240563 k-chain, dimer (9CI);(2S,3S,4S,5R,6R)-6-[[(4aR,6aR,6bS,8aS,14aR,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,13,14,14a-tetradecahydropicen-3-yl]oxy]-3,5-dihydroxy-4-[(1R,2R,3S,4R)-2,3,4-trihyd;ImmunoglobulinG1, anti-(human interleukin 5) (human-mouse monoclonal SB-240563 g1-chain),disulfide with human-mouse monoclona;Bosatria;Sb 240563;mepolizumab;Immunoglobulin G1, anti-(human interleukin 5) (human-mouse monoclonal sb-240563 gamma1-chain), disulfide with human-mouse monoclonal sb-240563 kappa-chain, dimer;Mepolizumab
pH value
Corresponds to reference standard： PASS
Non-reduced CE-SDS
98.3%
SEC-HPLC
99%
Isoelectric Point
Corresponds to reference standard
Bacterial Endotoxins Test
＜1 EU/ml
Residual Proteins of Host Cell
Exogenous Residual DNA
＜1 pg/mg
Residual protein A
＜1 ng/mg
Biological Activity
Compared with standard, the range ofbiological activity is 99%
Osmolality
Corresponds to reference standard: PASS
Peptide mapping
Corresponds to reference standard: PASS
N-terminal sequence
Corresponds to reference standard:PASS
References
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