Noscapine, also known as Narcotine, Nectodon, Nospen, Anarcotine and (archaic) Opiane, is a benzylisoquinoline alkaloid from plants of the poppy family, without painkilling properties. This agent is primarily used for its antitussive (cough-suppressing) effects. Noscapine's antitussive effects appear to be primarily mediated by its σ–receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a σ-specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine. Noscapine, and its synthetic derivatives called noscapinoids, are known to interact with microtubules and inhibit cancer cell proliferation.
Noscapine HCl was discontinued.
Cat.No
DC32214
Name
Noscapine Hydrochloride
Chemical Properties
CAS
912-60-7
Formula
C22H24CLNO7
MW
449.88
Storage
References
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