PF05020182 Datasheet DC Chemicals
Description PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures.
Cat.No DC32784
Name PF05020182

Chemical Properties

CAS 1354712-92-7
Formula C18H30N4O4
MW 366.46
Storage

References

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