α-Amyloid Precursor Protein Modulator(TPPB) Datasheet DC Chemicals
Description
α-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.
Cat.No
DC8534
Name
α-Amyloid Precursor Protein Modulator(TPPB)
Chemical Properties
CAS
497259-23-1
Formula
C27H30F3N3O3
MW
501.55
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
[1]. Kozikowski AP, et al. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. J Med Chem. 2003 Jan 30;46(3):364-73.
[2]. Yang HQ, et al. Neuroprotective effects of new protein kinase C activator TPPB against Aβ????? induced neurotoxicity in PC12 cells. Neurochem Res. 2012 Oct;37(10):2213-21.
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