PROTAC HIF-1α degrader-2 Datasheet DC Chemicals

Description	PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex. PROTAC HIF-1α degrader-2 inhibits HeLa cell proliferation, migration, and colony formation, and induces apoptosis. PROTAC HIF-1α degrader-2 reduces p-MEK and p-AKT expression in the MAPK and PI3K/AKT pathways. PROTAC HIF-1α degrader-2 can be used for the study of cervical cancer. (Pink: HIF-1α ligand ; Blue: VHL ligand ; Black: linker).
Cat.No	DC81378
Name	PROTAC HIF-1α degrader-2

Chemical Properties

CAS	3071964-44-5
Formula	C38H35F3N6O6
MW	728.72
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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