NLRP3-IN-87 Datasheet DC Chemicals

Description	NLRP3-IN-87 is a selective and orally active NLRP3 inhibitor with a Kd of 0.23 μM. NLRP3-IN-87 binds directly to the NLRP3 NACHT domain, disrupts NLRP3-NEK7 and NLRP3-ASC interactions, inhibits ASC oligomerization, and blocks inflammasome assembly. NLRP3-IN-87 suppresses caspase-1 activation and IL-1β secretion. NLRP3-IN-87 exhibits anti-inflammatory and analgesic activity, reducing joint swelling, inflammation, and pain in an MSU-induced acute gout mouse model. NLRP3-IN-87 can be used for the research of gout.
Cat.No	DC81159
Name	NLRP3-IN-87

Chemical Properties

CAS	3027967-95-6
Formula	C23H20F3N7O
MW	467.45
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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