Serum protein is the most abundant protein in plasma. Each protein molecule can carry seven fatty acid molecules. These fatty acid molecules bind to gaps in the protein, where their carbon-rich tails are buried safely away from surrounding water molecules. Serum proteins can also carry many other molecules that are insoluble in water. Serum proteins, in particular, can carry many drug molecules, such as ibuprofen. Human serum albumin (HSA) is a highly water-soluble globular monomer plasma protein with a relative molecular weight of 67KDa, composed of 585 amino acid residues, one sulfhydryl group and 17 disulfide bonds. In nanoparticle carriers, HSA nanoparticles are characterized by their ability to bind to various drug molecules, stability during storage and in vivo use, non-toxicity and antigenicity, biodegradability, repeatability, amplification of the production process and better control of release characteristics
