RGD's receptors are integrins αvβ3 and αvβ5, which can mimic cell adhesion proteins and bind specifically to 11 kinds of integrins, which can effectively adhere to biological materials. DSPE-PEG-RGD can be used to make micelles and vesicles. The liposomes formed by RGD-PEG-DSPE can act directly on the target to form an active targeting effect. Rgd-peg-dspe peptide RGD polyethylene glycol phospholipid can be used for passive targeting of micelles and vesicles, active targeting research and drug delivery. DSPE (1, 2-distearoyl-SN-glycerol-3-phosphate ethanolamine) is a saturated 18-carbon phospholipid commonly used in the synthesis of liposomes. Polyethylene glycol (PEG) -coupled DSPE is hydrophilic and can be used for drug delivery, gene transfection, and biomolecular modification. Polyethylene glycol can enhance solubility and stability, reduce the nonspecific binding of charged molecules, and reduce the immunogenicity of polypeptides.
